Novel Trilaminar Polymeric Antiadhesion Membrane Prevents Postoperative Pericardial Adhesion

BackgroundPostoperative pericardial adhesion formation is a prominent cause of morbidity and death in cardiovascular surgery, but there still no ideal prevention method, especially redo cases. This study investigated novel antiadhesion trilaminar polymeric film compared with the Gore PRECLUDE Pericardial Membrane (W. L. & Associates, Flagstaff, AZ) negative control.MethodsOur membrane composed polyvinyl alcohol (PVA) carboxymethylcellulose (CMC). An established rabbit model was used to test property membrane. After sternotomy, portion pericardium resected epicardium abraded. Rabbits (n = 24) were randomly assigned 3 groups: control group, or expanded polytetrafluoroethylene (ePTFE); ePTFE group (PVA-CMC group). Evaluation performed by resternotomy 4 weeks after operation.ResultsThe degree tissue surrounding heart PVA-CMC significantly less than (P < .01) .05) groups. The inflammation score lower that fibrosis groups.ConclusionsThe effectively reduced postoperative adhesions. placement at time sternal closure provides combination minimize extent severity adhesions while providing physical barrier between sternum cardiac structures. Postoperative control. Our operation.